CGP-74514A hydrochloride

CAS No. 481724-82-7

CGP-74514A hydrochloride ( CGP74514A )

Catalog No. M14612 CAS No. 481724-82-7

CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM; induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CGP-74514A hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM; induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells.
  • Description
    CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM; induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells; increases p21(CIP1) expression, p27(KIP1) degradation, diminished E2F1 expression, and dephosphorylation of p34(CDC2).
  • Synonyms
    CGP74514A
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    481724-82-7
  • Formula Weight
    422.35
  • Molecular Formula
    C19H24ClN7 · HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN1C=NC2=C(NC3=CC=CC(Cl)=C3)N=C(N[C@H]4[C@@H](N)CCCC4)N=C12.[H]Cl
  • Chemical Name
    N2-((1S,2R)-2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dai Y, et al. Cell Cycle. 2002 Mar-Apr;1(2):143-52.
2. Yu C, et al. Cancer Res. 2003 Apr 15;63(8):1822-33.
3. Dai X, et al. Cell Cycle. 2012 Aug 15;11(16):3079-86.
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